If you are going to be subject to inspection you will need to build a proper spray booth. If you are working from an unregulated area like out in the county or from your garage and no one officially is aware of you then safety is your only concern. Calculate the CFM rating of your exhause fan based on changing the entire air in your shop about 10 to 12 times an hour. Anything more than that and you will create too much of a draft. Much less than that and you will be creating a vapor cloud. The cloud will definitely be very unhealthy from an inhalation point of view and possibly explosive depending on what you are spraying.
Regardless what you spray, I would also suggest HVLP to really keep the vapors down.
Tony B Retired woodworker, among other things.
"Strive for excellence and settle for completion" Tony B