I first install the drawer box(s) in the opening(s). They may or may not be perfectly centered on the opening, but that doesn't matter. You may have two conditions to deal with. One may be that there are cross rails that indemnify each drawer, or, that the drawers are a stack with no cross rails.
If there are cross rails...
When the drawer is in the opening and pushed to a closed position, you can determine the spacing and use shims to center the drawer front. Use a couple of strips of double sided tape vertically on the the front of the box. The tape can be the thin carpet type, not the foam type that has some thickness. Set the front in with the shims and press the front against the box. Then very carefully, remove the drawer with the front, place the front face down and insert two screws.
If there are no cross rails...
Start with the bottom drawer, and like the above install the drawer box. Use shims for the underside of the front and the sides, and press the front onto the drawer box. Remove the drawer and front as above, and install two screws from inside the box into the drawer front. Then, put that drawer back into the opening, and use shims on top of the first drawer front to align the second one up.
Or, you can install all the drawer boxes, and starting from the bottom, apply the shims for alignment, start stacking all the drawer fronts (with shims) and press them on. Carefully remove them one at a time and install screws from the inside.
You can also use drawer front adjusters like these
. With them, you drill out one hole in the face of the box, and insert the adjuster. It allows concentric movement with the drawer front. In lieu of buying these, you could just make a slightly oversized hole in the front of the drawer box, and use a screw and washer.
When drawers are installed in a cabinet, their drawer front alignment can be racked if the cabinet is not sitting flat and square. IOW, if you installed all the drawers and fronts with it sitting on your floor, or bench, it could sit differently where it is finally placed. You can see the shift in alignment if you just lift one of the corners at a time.
Because of this, it is at times a good idea to make that final alignment once the cabinet is set. If the cabinet gets screwed to the wall, the method of shimming one corner could bring all the fronts into alignment.